coenzyme Q10
coenzyme Q10
CAS: 303-98-0
Molecular Formula: C59H90O4
coenzyme Q10 - Names and Identifiers
| Name | coenzyme Q10 |
| Synonyms | QH 10 Co Q10 Conzyme Q10 coenzyme Q10 ubidecarenone coenzyme Q-10 Coenzymen Q10 Water-soluble QH10 CoenzymeQ10Usp27Ep5 CoQ10 Ubidecarenone coenzyme Q10 synthetic LABOTEST-BB LT00244787 Coenzyme Q10 standard CoenzymeQ10Ubidecarenone Hydrosoluble Coenzymen Q10 Water-soluble Coenzymen Q10 Coenzyme Q10 (Water soluble) 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione |
| CAS | 303-98-0 |
| EINECS | 206-147-9 |
| InChI | InChI=1/C59H90O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+ |
| InChIKey | ACTIUHUUMQJHFO-DQXDOXBUSA-N |
coenzyme Q10 - Physico-chemical Properties
| Molecular Formula | C59H90O4 |
| Molar Mass | 863.34 |
| Density | 0.9145 (rough estimate) |
| Melting Point | 49-51°C |
| Boling Point | 715.32°C (rough estimate) |
| Flash Point | 324.5°C |
| Solubility | Soluble in chloroform, benzene, carbon tetrachloride, soluble in acetone, ether, slightly soluble in ethanol, insoluble in water, methanol. |
| Vapor Presure | 1.23E-30mmHg at 25°C |
| Appearance | Yellow crystalline powder |
| Color | Light Orange to Dark Orange |
| Merck | 14,9843 |
| BRN | 1900141 |
| Storage Condition | -20°C |
| Stability | Stable, but may be light or heat sensitive. Store in the dark at -20 C. Incompatible with strong oxidizing agents. |
| Sensitive | Light Sensitive |
| Refractive Index | 1.4760 (estimate) |
| MDL | MFCD00042919 |
| Physical and Chemical Properties | Properties: yellow or orange-yellow crystalline powder; Odorless and tasteless; Easy to decompose in light melting point 48-52°C |
| Use | Can be widely used in food, cosmetics, dietary supplements and other industries. |
coenzyme Q10 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | DK3900000 |
| FLUKA BRAND F CODES | 8-10 |
| TSCA | Yes |
| HS Code | 29146990 |
| Toxicity | LD50 intramuscular in mouse: > 500mg/kg |
coenzyme Q10 - Reference
| Reference Show more | 1. Lu Simin, Zhang Liting, He Xiaobing, etc. Observation on content changes of four kinds of coenzyme Q_(10) soft capsules after natural storage for 180 days [J]. Guangzhou chemical industry, 2019, v.47(22):117-120. 2. [IF = 9.933] Zhen Jiang et al."Surfactant-Stripped micells with Aggregation-Induced Enhanced Emission for Bimodal gum Imaging In Vivo and Microbiota Tagging Ex Vivo. Advanced Healthcare Materials. 2021 Jun 23 3. [IF = 3.375] Xing Li et al."Coenzyme Q10 suppresses oxidative stress and apoptosis via activating the Nrf-2/NQO-1 and NF-κB signaling pathway after spinal cord injury in rats."Am J Transl Res. 2019; 11(10): 6544-6552 |
coenzyme Q10 - Introduction
Open Data Unverified Data
Coenzyme Q10 is a fat-soluble antioxidant, which can activate the nutrition of human cells and cell energy, and has the functions of improving human immunity, enhancing antioxidation, delaying aging and enhancing human vitality, it is widely used in cardiovascular diseases in medicine, and widely used in nutrition and health products and food additives at home and abroad. Coenzyme Q10 was first discovered in the United States in 1957. In 1978, Dr. Peter mcker of the University of Edinburgh received the Nobel Prize for his contribution to the study of the relationship between Coenzyme Q10 and cellular energy.
Last Update：2022-01-01 08:47:53
coenzyme Q10 - Physical and chemical properties
Open Data Unverified Data
- Coenzyme Q10 (CoEnzymeQ10), also known as Ubiquinone (UQ), is a fat-soluble quinone compound existing in nature, and has a structure similar to vitamin K, vitamin E and hydroquinone. In the human body cells involved in energy production and activation, is the prevention of arteriosclerosis formation of the most effective antioxidant ingredients.
- The ubiquinone molecule contains a side chain consisting of a plurality of isoprene units attached to the parent core of p-benzoquinone, the length of which varies depending on the origin of the ubiquinone, it generally contains n = 6-10 isoprene units. For mammals, n = 10, thus also known as Coenzyme Q10.
- the quinone structure in the molecule makes ubiquinone have two forms: oxidized (ubiquinone, Coenzyme Q10) and reduced (Ubiquinol, Ubiquinol), these two forms can be converted into each other in cells, which is the basis of ubiquinone as an electron transport body. The gain and loss of electrons in ubiquinone can be carried out in two steps, that is, one electron can be transferred at a time, or two electrons can be transferred simultaneously in one step.
- ubiquinone is present in most eukaryotic cells, especially mitochondria. It is one of the components of the respiratory chain; Its content in the inner mitochondrial membrane is much higher than the content of other components of the respiratory chain, and the fat solubility makes it highly mobile on the inner membrane, it is particularly suitable as a mobile electron transport body.
- the benzoquinone moiety in ubiquinone is synthesized in vivo using tyrosine as a raw material, while the isoprene side chain is synthesized from acetyl-CoA raw material via the mevalonate pathway. Thus, beta-blockers and statins, which act by blocking the mevalonate pathway, also affect the synthesis of ubiquinone in vivo when used.
trait
yellow or light yellow crystalline powder
Solubility
soluble in chloroform, benzene, carbon tetrachloride, soluble in acetone, ether, ethanol-soluble, insoluble in water, methanol
melting point
49℃
Stability
light is easily decomposed
Coenzyme Q10 in the organs (heart, liver, kidney), beef, soybean oil, sardines, mackerel and peanuts and other food content is relatively high, intake of about 1kg of sardines, 2 catties of beef or 3 catties of peanuts can provide about 30mg of coenzyme Q10, respectively.
Coenzyme Q10 was discovered in 1957, identified by Dr. Karu rufalkas in 1958 as the chemical structure, and received the highest honor of the American Chemical Society, known as the father of the study of coenzyme Q10, at the time he proposed that coenzyme Q10 plays an important role in heart function. In real life, Dr. Karufu rukas, who had been taking Q10 for 40 years until his death at the age of 91, was an active-duty professor who had been actively engaged in scientific research activities.
Last Update：2022-01-01 08:47:53
coenzyme Q10 - Nature
Open Data Verified Data
- This strain was prepared by extracting from porcine heart residue after extraction of cytochrome C. Yellow or light orange crystalline powder, odorless and tasteless, melting point of 47~52 ℃, soluble in chloroform, benzene, acetone, petroleum ether, ether, ethanol-soluble, insoluble in water and methanol. Easy to decompose in light, so that the color darkened. In the presence of a reducing agent, it can be converted into colorless reduced coenzyme Q10, which in turn can be oxidized into oxidized coenzyme Q10. The ethanol solution of oxidized Coenzyme Q10 has a maximum absorption at 275nm and a broadband absorption at 405nm. The absorption peaks of reduced coenzyme Q10 disappeared at 275nm and 405nm, and the maximum absorption appeared at 290nm.
- Coenzyme Q10 is a proton translocator and electron transporter in the respiratory chain of biological cells. Chemically, it is a group of fat-soluble quinone compounds, different sources of coenzyme Q, its side chain isopentene unit number is different, human and mammal is 10 isopentene unit. This product is a metabolic activator, can activate cell respiration, accelerate the production of adenosine triphosphate (ATP). It is a natural antioxidant produced by the cell itself, which can inhibit the peroxidation of mitochondria and protect the structural integrity of the biofilm. It has non-specific enhancing effect on immunity, can increase the phagocytic rate of phagocytes, increase the production of antibodies and improve the function of T cells.
Last Update：2024-01-02 23:10:35
coenzyme Q10 - Preparation Method
Open Data Verified Data
- Alcohol-alkali saponification production method. After the extraction of cytochrome C, the heart residue was rinsed with water to remove (NH4)2 S04 and fat, spin dried, and then mixed with pyrogallic acid. In addition, add about 2 times the amount of ethanol in the reflux tank, add solid caustic soda, stir and dissolve, and prepare alcohol alkali solution with alkali concentration of about 10%(W/V), then put the slag mixed with pyrogallic acid, quickly heated to boiling, reflux 25~30min saponification. Then it was rapidly cooled to room temperature, and an appropriate amount of 120# gasoline was added to the cooled saponified product, followed by extraction three times to complete the extraction. The extracts were combined and washed repeatedly with water to near neutrality. The extract after washing with water was concentrated to about 1/10 of the original volume under reduced pressure, and precipitated impurities (mainly cholesterol) were removed by low-temperature filtration. The clear filtrate was added to a silica gel column. First, the impurities were removed by washing with No. 120 gasoline, and then eluted with a mixture of ether and steam and oil (1:10, volume ratio), and the eluent of the yellow band portion was collected. In the yellow oily eluent, add the appropriate amount of anhydrous ethanol, warm to dissolve completely. Filtration while hot, The filtrate was placed in a refrigerator to complete crystallization. The crystals were filtered, recrystallized in anhydrous ethanol or chromatographed on silica gel column to obtain Coenzyme Q10 with higher purity. In addition to the above saponification method, there are solvent direct extraction method and solvent extraction saponification method. The yield of the solvent extraction method was not as good as that of the saponification method, but the application of pyrogallic acid was omitted. Larger amounts of pyrogallic acid may produce ethoxy derivatives during the saponification process, which may also be filled with nitrogen. N-hexane, n-heptane, isooctane, cyclohexane, diethyl ether and mixed solvents of ethanol and diethyl ether can be used to extract coenzyme Q10. The adsorbent for chromatographic purification can be silica gel, alumina and the like.
- Alcohol-ether mixed preparation extraction method.
- microbial cell culture method: the main strains for CoQio production can be used as the red pole of the red pole of the bacteria, the nitrogen removal of the pole of the bacteria, the methane micro ring bacteria and the like.
Last Update：2022-01-01 11:13:52
coenzyme Q10 - Pharmacological action
Open Data Unverified Data
- can reduce the attenuation of myocardial contractility and decrease the contents of creatine phosphate and adenosine triphosphate during acute ischemia, and maintain the morphological structure of mitochondria in ischemic myocardial cells, it has a protective effect on ischemic myocardium.
- increasing cardiac output and reducing peripheral resistance are beneficial to anti-heart failure therapy, and may inhibit the synthesis and secretion of aldosterone and block its effect on renal tubules.
- Perfusion of isolated ventricular muscles of animals under hypoxic conditions can shorten the duration of action potential and produce a higher threshold of ventricular arrhythmia than that of control animals.
- can decrease peripheral vascular resistance and has anti-Aldosterone effect.
- Coenzyme Q10 has cardiotoxic and hepatoprotective effects of adriamycin.
Last Update：2022-01-01 08:47:54
coenzyme Q10 - Use
Open Data Verified Data
- activators of cellular respiration and cellular metabolism are also non-specific immune enhancers of the body. For acute and chronic viral hepatitis, subacute liver necrosis and other diseases, but also for the adjuvant treatment of cancer, bacterial and viral infections.
- Coenzyme Q10 is an important member of the mitochondrial electron transport chain and plays an important role in oxidative phosphorylation. Can be used for the treatment of heart disease, such as myocardial infarction, narrow the heart and so on.
Last Update：2022-01-01 11:13:53
coenzyme Q10 - Indication
Open Data Unverified Data
- treatment of heart failure and dilated cardiomyopathy: Coenzyme Q10 has an excellent repair effect on myocardial cell defects caused by ischemic (hypoxic) heart disease, for myocardial hypertrophy and dilated cardiomyopathy have significantly improved.
- hypotensive and hypolipidemic effects: a 12-week, double-blind trial of 46 men and 37 women with high blood pressure found 120 mg/day of the patients, blood pressure decreased on average by about 17mm Hg.
- Antioxidant, cardiovascular system applications: Prevention of atherosclerosis, myocardial infarction and thrombosis, coenzyme Q10 as a strong antioxidant, can resist the oxidation of low density lipoprotein in the blood, reduce the formation of arteriosclerosis, prevention of myocardial infarction and thrombosis.
- treatment of congestive heart failure: in, scientists Folkers proved by clinical trials that compared with traditional drugs, 100 mg of coenzyme Q10 per day for two consecutive months, heart function was significantly improved in two thirds of the patients.
- for heart disease after surgical treatment: Consumption of coenzyme Q10 than unused patients, recovery time is greatly reduced.
- delay the development of heart failure, decreased by Case Fatality Rate: can treat chest pain caused by coronary artery narrowing. Enhance the ability of heart beating, hypoxia tolerance.
- Beauty Anti-Aging: help the skin to prevent DNA oxidative damage, anti-photoaging, reduce wrinkles. It is also commonly used in various anti-wrinkle, skin repair and skin tightening formulations. However, extensive studies suggest that exogenous Coenzyme Q10 is far less direct and effective than endogenous Coenzyme Q10 supplementation in resisting human aging.
- Anti-Fatigue: it has the function of protecting and restoring the integrity of the biofilm structure and stabilizing the membrane potential. It is a non-specific immune enhancer of the body, so it shows excellent anti-fatigue effect, keep the cells in good health.
Last Update：2022-01-01 08:47:54
coenzyme Q10 - Safety
Open Data Verified Data
It was kept in a cool, dark and dry place.
Last Update：2022-01-01 11:13:53
coenzyme Q10 - Toxicity
Open Data Unverified Data
in acute toxicity test, the LD50 of mice and rats was more than 4000mg/Kg. In the subacute toxicity test, male and female Wistar rats were given 40mg, 200mg and 1000mg/Kg daily for 5 weeks, and male and female rabbits were given 6mg, 60mg and 600mg/Kg daily for 23 days, there were no special changes in blood, urine examination and morphological observation of the animals. In the chronic toxicity test, male and female Wistar rats were given 6mg, 60mg and 600mg/Kg daily for 26 consecutive weeks. There were no special changes in the general state, blood and urine examination and morphological observation of the animals.
Last Update：2022-01-01 08:47:55
coenzyme Q10 - Production method
Open Data Unverified Data
Semi-synthesis
The semi-synthetic process developed at present is to obtain Coenzyme Q10 by bromination, etherification and oxidation of p-methylphenol as raw material to obtain methyl dimethoxy benzene, and then condensation with solanesol extracted from tobacco or potato leaves. The key to this approach is how to attach the side chain to the parent ring.
total synthesis
The total synthesis process developed by Eem and Kanan in 1988 to produce Coenzyme Q10 is the only successful total synthesis technology at present, but it is difficult to synthesize the linear unsaturated side chain. And the synthesis conditions are harsh, and there is a certain distance from industrialization.
fermentation method
The production of coenzyme Q1o by microbial fermentation was realized in 197. This production process is considered to be the most promising synthesis process. In recent years, microbial fermentation has become a hot spot of development at home and abroad. The main strains for producing Coenzyme Q10 were tricylobacter rugosa, tricylobacter denitrificans, and methanogens.
plant cell culture method
The Plant Cell culture technique is a technique in which a part of a plant body is aseptically treated, and then placed on an artificial medium to proliferate its cells, and then cultured as needed. All parts of the plant, such as roots, stems, leaves, flowers, fruits, anthers and pollen, can be used as explants to start cell culture, the transfer of callus to a liquid medium for culture is called suspension culture.
Biological extraction method
- Alcohol-alkali saponification production method the yield of coenzyme Q10 in this process is 61.2mg kg fresh pig heart, which is a commonly used process in China. In the presence of ethanol, long-term saponification may result in transposition of methoxy groups in Coenzyme Q10 and ethoxy groups in ethanol to produce mono-or BIS-ethoxy derivatives, in order to avoid the formation of these impurities. KOH can be used instead of NaOH and methanol saponification, but also must be added pyroic acid, otherwise Coenzyme Q10 in the saponification process is completely destroyed, the amount of 5%-7% of the starting material, nitrogen can be introduced into the saponification process.
- Alcohol-ether mixed extraction method, the process of alcohol-alkali saponification manufacturing process is similar, but the saponification reaction is omitted. Biological extraction is the world's oldest basic production process, for some time was the only method of production of Coenzyme Q10. However, due to the low content of coenzyme Q10 in animals and plants, the complex chemical composition and the limited source of raw materials (mainly extracted from fresh liver of animals), the products are of high cost and high price, large-scale production has been limited.
Last Update：2022-01-01 08:47:56
coenzyme Q10 - Pharmacokinetics
Open Data Unverified Data
Coenzyme Q10 is easily absorbed by oral administration. Male Wistar rats and rabbits were orally administered with 0.6mg/Kg Coenzyme Q10, after 1 hour and 2 hours, the highest blood drug concentration was reached, and then it was 1.9% in the urine of blood rats, 85% in the feces, and 2.9% in the urine of rabbits, 91% in feces. No human pharmacokinetic data.
Last Update：2022-01-01 08:47:57
coenzyme Q10 - The father of the study
Open Data Unverified Data
Coenzyme Q10 was discovered in 1957, and its chemical structure was identified by Dr. caruforucas, the father of coenzyme Q10 research, at the University of Texas, in1958, for this reason, he received the highest honor of the American Chemical Society-Priestly Medical. In real life, he took Q10 for more than 40 years until he died at the age of 91. This also makes him has been recognized as one of the most energetic professor.
Last Update：2022-01-01 08:47:57
coenzyme Q10 - Applicable population
Open Data Unverified Data
- athletes, mental workers, people with poor immunity, appropriate supplementation of coenzyme Q10 will be of great benefit;
- Coenzyme Q10 supplementation in patients with heart disease, periodontitis, gastric ulcer, Alzheimer's disease, diabetes helps to improve the condition;
- gingival bleeding in severe cases in addition to vitamin C, should also be more intake of Coenzyme Q10.
Last Update：2022-01-01 08:48:00
coenzyme Q10 - How to Choose
Open Data Unverified Data
A look at the production process
The production process of coenzyme Q10 is varied, and there are five methods, such as biological extraction method, animal and plant cell culture method, semi chemical synthesis method, full chemical synthesis method and microbial fermentation method. Among them, coenzyme Q10 prepared by biological extraction method, semi-chemical synthesis method and full chemical synthesis method has certain defects, which may have an impact on human health. Only the microbial fermentation method is the most advanced, the production of coenzyme 10 is of great help to health. The regret of microbial fermentation is the high cost, which is 2-3 times of other processes.
two look at the purification technology
high temperature purification is easy to lose the activity of enzyme, low temperature and ultra low temperature purification method of coenzyme Q10 quality.
three look at scientific research power
modern society is a science and technology society, and the quality of products is often determined by its scientific research team.
Four look at the production line:
coenzyme products with soft capsules are most easily absorbed by the human body, hard capsule absorption is not ideal. Production enterprises must pass the national GMP or EU GMP certification.
also need to choose according to the physical condition of the taking personnel
- two forms of coenzyme Q10: Ubiquinol-Ubiquinol, Ubiquinone. Among them, Ubiquinol-panthenol is more easily absorbed by the human body and suitable for older people with relatively low metabolic capacity. And relatively for the usual as health care products are not required in this regard. Generally younger people take little demand, can be converted into Ubiquinol in the body.
- In addition, when purchasing, you need to check the concentration and content. Many merchants are labeled 500mg or more, but in fact 500mg is the weight of the entire pill. Generally labeled "X grams of CQ10 per 100 grams", or "greater than how much". A lot of calculated CQ10 content is 100mg or less, and then consider whether the human body absorption factors: if the maintenance of healthy body needs, about the daily dosage is 30-60mg is enough, if the individual factor pathology needs to be increased to 100-300mg, it is recommended to take it several times a day and absorb about 60mg-100mg each time. Not recommended daily intake of more than 400mg of the amount of absorption does not make sense. In addition, it is not recommended to take high concentrations for a long time, which will lead to defects in the ability to synthesize coenzyme Q10.
Coenzyme Q10
The clinical detection of coenzyme Q10 is difficult, but it is of great significance. The clinical detection of coenzyme Q10 is mainly to detect the concentration in plasma.
- plasma CoQ10 content is Mortality Rate independent predictor of chronic heart failure. The lower the CoQ10 concentration and CoQ10/lipid ratio, the lower the survival rate. CoQ10 deficiency may be an important pathogenesis of chronic heart failure.
- plasma CoQ10 content is an important indicator of cardiovascular disease. A large number of clinical studies have found that the plasma CoQ10 level is significantly lower in patients with cardiovascular disease, therefore, it is considered that people with low plasma CoQ10 levels are more likely to suffer from cardiovascular and cerebrovascular diseases.
Last Update：2022-01-01 08:48:02
coenzyme Q10 - Functional use
Anti-Aging
- Coenzyme Q10 has two main functions in the body. One is that it plays an important role in the process of energy conversion in mitochondria, and the other is that it has obvious anti-lipid peroxidation effect. It is an energy converter in the mitochondria of cells that participates in the "tricarboxylic acid cycle" by transferring and transmitting electrons to produce ATP (adenosine triphosphate), an energy factor for cellular metabolism. At the age of 20, the ability of self-synthesized Coenzyme Q10 reached its peak, and maintained to about 50 years old. Later will decline year by year, because the storage of coenzyme Q10 cell mitochondrial DNA material is destroyed by oxygen free radicals, resulting in the reduction of self-synthesis of Coenzyme Q10. As a result, the metabolic function of human cells, especially heart cells, decreased, and the "old dragon clock" appeared.
- the experiment proves that coenzyme Q10 in vivo can directly react with peroxide radicals and regenerate vE by changing into alcohol form, and exert the effect of antioxidant independently and synergistically with vE. In vitro experiments also found that the antioxidant Coenzyme Q10 can protect mammalian cells from mitochondrial oxidative stress-induced apoptosis, and tumor necrosis factor-(TNF-) or oncogene inhibitors have no such effect, clinical studies have shown that oral Coenzyme Q10 for the treatment of Parkinson's disease, Huntington's disease and Alzheimer's disease and other mitochondrial dysfunction and aging related neurodegenerative diseases have a significant effect.
- the relationship between aging and mitochondrial coenzyme Q10 concentration shows that the decrease of mitochondrial coenzyme Q10 concentration is an important aspect of skeletal muscle aging. An experimental study of aging rats showed that the content of coenzyme Q10 in heart mitochondria of aging rats was decreased, and the content of coenzyme Q10 in liver and skeletal muscle was lower. The decline in immune function with age is the result of free radical and free radical reactions. Coenzyme Q10 is a potent antioxidant and free radical scavenger, which is embedded in the inner mitochondrial membrane lipid bimolecular as a component of the mitochondrial respiratory chain, the two electrons received from the mitochondrial complex I or complex II are then converted to alcohol, and the electrons are transferred to complex III. Coenzyme Q10 in the body is largely consumed into alcohol, which is both an effective antioxidant and an electron carrier for movement, and it converts hydrogen atoms from their hydroxyl groups to lipid peroxidation free radicals, the lipid peroxide response in the inner mitochondrial membrane is thus reduced. In this process, a free radical pansemiquinone, which is not proportional to the alcohol form of coenzyme Q10 and coenzyme Q10, or reacts with oxygen to form superoxide, free radical ubiquinone in the role of superoxide dismutase and catalase transport free radicals to achieve detoxification, so that the circulation of the respiratory chain will be Coenzyme Q10 continuously regenerated alcohol, restore its antioxidant activity.
- The decline in immune function with age is the result of free radicals and free radical reactions, coenzyme Q10 as a strong antioxidant used alone or with vitamin B6 (pyridoxine) the combined use can inhibit the modification of the microtubule system of the receptors on immune cells, which is related to cell differentiation and activity, enhance the immune system and delay aging.
- the increase of wrinkles and the aging of the skin are related to the content of Q10. The lower the content, the more the skin is aged, and the more the facial wrinkles are. Q10 can be taken orally, when the cells contain enough Q10 that the energy metabolism will be enhanced, scavenging free radicals, ease wrinkles aggravated.
- In addition, skin care products containing Coenzyme Q10 can also be rubbed, and the absorption of coenzyme Q10 by cells can be increased by improving external use, thereby reducing the formation of wrinkles.
Anti-Fatigue
- in the mid -70 s, the theory of Miller's chemical permeability hypothesis revealed the energy conversion in vivo and the important role of coenzyme Q10 in the mitochondrial energy conversion system.
- Coenzyme Q10 is a coenzyme of at least three mitochondrial enzymes (multienzyme complexes I, II and III), its chemical structure is a 2,3 dimethoxy 5 methyl 1,4 benzoquinone derivative with a ten unit isoprene side chain attached to the carbon at position 6.
- its quinone ring plays a role in the transfer of electrons and protons in the oxidative respiratory chain. This role is not only essential for all forms of life, but also the key to the formation of ATP. ATP is the main form of storage of the body's energy, but also an important basis for the normal functioning of all cells, Coenzyme Q102.2 detection wavelength: the biological activity of 275nm mainly comes from the redox characteristics of its quinone ring and the physical and chemical properties of its side chain. It is a natural antioxidant and cell metabolism promoter produced by the cell itself, which can protect and restore the integrity of the biofilm structure and stabilize the membrane potential. It is a non-specific immune enhancer of the body, therefore, it shows an excellent anti-fatigue effect. Coenzyme Q10 keeps the cells in a good and healthy state, so the body is full of vitality, energy and energy.
Antioxidant
- the etiology and pathology of chronic fatigue syndrome (CFS) are still unclear, and studies have shown that oxidative stress is a cause of the disease, experiments found that CFS patients have different degrees of oxidative stress, although the oxidative damage is the cause of the disease or the results need to be further observed, but the antioxidant Coenzyme Q10 has been successfully used in the prevention and treatment of chronic fatigue syndrome.
- In addition, the antioxidant activity of coenzyme Q10 makes it have a certain inhibitory effect on the formation and development of atherosclerosis. And its oxidation resistance makes the membrane stable, metabolic cardiac and reverse left ventricular hypertrophy and other good effects, in cardiovascular disease is increasingly widely used.
Anti-Tumor
research shows that coenzyme Q10 has anti-tumor effect, clinical for advanced metastatic cancer has certain curative effect, in the prevention of coronary heart disease, relieve periodontitis, the treatment of duodenal ulcer and gastric ulcer, enhance Human immune function and relieve angina pectoris has a significant effect.
Security
Since coenzyme Q10 is an OTC product on the US and European markets, and several well-designed clinical trials have shown that oral Coenzyme Q10 is beneficial for a variety of cardiovascular diseases, therefore, based on its efficacy and safe and reliable characteristics, even for a long time, oral administration of large doses of coenzyme Q10, patients can be well tolerated.
Antihypertensive
significant research conducted by the Argentina Institute of Neuroscience has shown that oral administration of 100mg of coenzyme Q10 within an hour in patients with high blood pressure can enhance brain treatment and agility.
Skin protection
- Local experiments show that with the increase of age, the ability of skin collagen to resist the damage of ultraviolet and other oxidative irritants decreases, and long-term use of coenzyme Q10 can effectively prevent skin aging and reduce wrinkles around the eyes, because the penetration of coenzyme Q10 into the skin growth layer can weaken the oxidation reaction of photons, with the help of tocopherol can start specific phosphorylated tyrosine kinase, prevent DNA oxidative damage, inhibit the expression of human skin fibroblast collagenase under ultraviolet light irradiation, protect the skin from damage. Extensive studies have shown that coenzyme Q10 inhibits lipid peroxidation, reduces the generation of free radicals, protects the active center of SOD and its structure from free radical oxidative damage, and improves the activity of SOD and other enzymes in vivo, inhibition of oxidative stress induced apoptosis, has a significant role in anti-oxidation, anti-aging.
- can deepen the cells, strengthen the metabolic function of the cells, and the ability of the active cells to tightly combine with each other. On the other hand, in the epidermal layer, the elastic network structure of the gel is indeed repaired due to the loss of water, and then achieve a real moisturizing effect.
- Features: can repair the skin of the skin, such as thin skin or skin atrophy caused by the use of medicinal cosmetics, can be used for 3-6 months to improve.
- for the introduction can increase the absorption of active ingredients, and increase the resistance of cells, the effect is the most perfect, improve the skin water shortage problem is more thorough. Coenzyme Q10 antioxidant, can eliminate free radicals, maintain the integrity and stability of the cell membrane.
heart protection
coenzyme Q-10 helps to provide sufficient oxygen to the myocardium and prevent sudden heart attack. Coenzyme Q10 plays a key role in the process of myocardial hypoxia.
Adjunctive drugs
statins inhibit cholesterol synthesis and also inhibit the production of coenzyme Q10 in the body. Elderly patients are more likely to suffer from Coenzyme Q10 deficiency, in the use of statin drugs must be supplemented with coenzyme Q10. Rapid relief of statin-induced myalgia and fatigue counteracts statin-related myalgia and liver damage.
Enhanced energy
- experiments show that coenzyme Q10 can greatly promote heart health, and an appropriate amount of coenzyme Q10 in the human body is necessary for proper muscle function. Biochemical analysis of muscle cell extract showed that the activity of mitochondrial complex I + II and complex I + III was seriously decreased when the concentration of coenzyme Q10 was lower than normal 20%.
- Several studies have clearly shown that supplementation of coenzyme Q10 at 100-150mg/day can significantly improve the condition of people suffering from muscular dystrophy. Strenuous physical exercise reduces the blood content of coenzyme Q10, and a daily supplement of 60mg has been found to improve the skills of athletes. Many overweight people have a very low content of coenzyme Q10, and the supplement can make them lose weight, this is because the role of coenzyme Q10 can accelerate the metabolism of fat, so that the limbs and brain energy supply, he has high energy.
Last Update：2024-04-10 22:29:15
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